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One can consider pharmacological venous thromboembolism prophylaxis as these patients are at increased risk as are patients with active ulcerative colitis (60). Abdominal and pelvic CT scans can be used as an adjunct to determine the severity and extent of disease and can detect colon wall thickening, ascites, megacolon, ileus, or perforation (41,65,66,67). We advocate its use in patients with complicated CDI if there is no immediate indication for operative intervention.
There are no RCTs available to guide recommendations for the choice and dosing of antibiotic therapy for the treatment of patients with severe CDI.