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liability scale) (Zammit et al. GRPS are quantitative scores calculated for each individual and are an estimate of an individuals' genetic risk for disease. GRPS were first applied to schizophrenia GWAS data where they provided evidence for a substantial polygenic component to the risk of schizophrenia involving many loci of very small individual effect (Purcell et al.
GRPS are constructed in two steps: firstly, individual effect sizes of risk alleles (e.beta from linear regression, odds ratio from logistic regression or best linear unbiased prediction (BLUP) from linear-mixed models (Yang et al.